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Cancer Research 

Cancer Research 

Conventional cancer models often fail to capture the complexity of the tumor microenvironment, leading to poor translation from lab to clinic. Our organ-on-chip technology creates dynamic systems that more closely resemble human biology, enabling researchers to generate insights and results that conventional approaches miss.

What you can do:


→ Recreate disease- and tumor-specific microenvironments
→ Enable monitoring of pathophysiology in real time
→ Study metastasis and immune interactions
→ Test novel therapies and drug combinations
→ Study systemic cancer effects with multi-organ interactions

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For example:

We have developed and validated breast and lung cancer models on chip. MCF-7 cells and spheroid fragments were cultured under flow, revealing altered cancer stem cell marker expression and differential drug response to 4-hydroxytamoxifen compared to static cultures

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Precision Medicine

Precision Medicine

Every patient is unique, yet conventional models often overlook this individuality. By integrating patient-derived cells and organoids into our organ-on-chip systems, we enable personalized testing that predicts individual drug responses and supports tailored therapy selection.

What you can do:

→ Patient-derived cell cultures and organoids on chip
→ Patient – specific personalised testing iPCSs
→ Predict individual drug responses
→ Support personalized therapy selection

For example:

Patient-derived NSCLC organoids were cultured in chips and exposed to cisplatin, demonstrating patient-specific cytotoxicity and biomarker expression under dynamic conditions

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Hypoxia

Hypoxia

Ineffective preclinical models can slow drug development and increase costs. Our organ-on-chip solutions bring human relevance into the early stages of discovery, supporting more informed decisions and accelerating the path toward clinical validation.

What you can do:

→ Validate novel drug candidates using physiologically relevant human models
→ Predict human responses earlier
→ Reduce costly late-stage failures
→ Robust and reproducible high-throughput assays

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Toxicology & Safety Assessment

Toxicology & Safety Assessment

With our platform, you can assess compound safety in human-relevant models, detect organ-specific toxicity, and capture both acute and long-term exposure effects that conventional systems often miss.

What you can do:


→ Organ-specific toxicity detection
→ Chronic and acute exposure testing
→ Enable long-term exposure studies and low-dose effects analysis

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Gut Research

Gut Research

With our platform, you can model metabolic cross-talk between organs, link microbiota activity to host responses, and generate reproducible data that accelerates the development of new therapies for metabolic disorders.

What you can do:


→ Study metabolic disorders such as NAFLD or diabetes
→  Evaluate Gut-Microbiota metabolism

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Microbiome and Host-Microbe Interaction

Microbiome and Host-Microbe Interaction

The human microbiome is vital for health and therapy response, yet hard to model with traditional tools. With our platform, you can create gut-like environments — with flow, oxygen control, and hypoxia — and extend them to other tissue–microbe systems for deeper insights.

What you can do:

→ Recreate gut–microbiome microenvironment with physiological flow and oxygen gradients
→ Study gut–microbiome interactions
→ Simulate hypoxia and shear stress
→ Supports sequencing, omics and advanced assays
→ Test drug candidates and dietary compounds

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EVs Application

EVs Application

Extracellular vesicles are emerging as key mediators of cell-to-cell communication in health and disease. With our platform, you can study EV-mediated signaling in controlled microenvironments and explore their role in disease mechanisms and therapeutic development.

What you can do:


→ Analyze extracellular vesicle-mediated signaling in disease and therapy

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Barrier Integrity

Barrier Integrity

Understanding immune responses requires models that capture the complexity of human biology. Our organ-on-chip technology provides a controlled environment to study immune cell behavior, barrier function, and cytokine signaling — supporting the development of next-generation therapies.

What you can do:

→ Reconstitute human immune responses under dynamic perfusion
→  Barrier integrity and cytokine signaling
→  Evaluate anti-inflammatory therapeutics

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Publications

Sorption and release of small molecules in PDMS and COC for Organs on chip

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Development of Organ-on-a-Chip System with Continuous Flow in Simulated Microgravity

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Personalized PDAC chip with functional endothelial barrier for tumour biomarker detection: A platform for precision medicine applications

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Projects

MIRACLE: Multi-modal Integrated Real-time Analyte Characterization for Living in vitro Environments

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Development of a novel microfluidic device for label-free quantification of prostate cancer-derived extracellular vesicles and analysis of their RNA content (PROCEX)

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Latvijas Investīciju un attīstības aģentūras atbalsts pasākuma "MVU inovatīvās uzņēmējdarbības attīstības programma” ietvaros

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Frequently Asked Questions

Organ-on-chip technology combines living cells with microfluidics to recreate tissue-specific microenvironments. With our platform, you can model and test cancer biology, drug absorption, metabolism, toxicity, immune responses, microbiome interactions, and more.

Our chips and instruments are user-friendly, saving time in experimental setup and reducing risks of technical error. This translates to faster workflows and shorter experimental cycles.

No. Our design does not rely on complex tubing systems. This minimizes leaks, reduces contamination risk, and makes the setup significantly easier to handle.

No. Our system supports integrated, in-chip microscopy, so you can monitor cells directly in real time without disturbing the experiment.

Yes. All chips are sterilized using ethylene oxide (EtO), ensuring safe and contamination-free experiments.

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Contract Research Services

We use primary cells, cancer cell lines, patient derived cancer cells, iPS-derived cells, and cell co-cultures.

Our services cover multiple application areas, each supported by dedicated assays to generate the most relevant data.

  • In in vitro pharmacology, we perform PK/PD studies, toxicity and efficacy testing, gene expression, imaging and cell functional assays.
  • For host–microbiota interaction, including strict anaerobes, we apply metagenomics, metabolomics, bacterial adhesion, and pre/probiotic validation.
  • In biological barrier transport and integrity, we measure induced permeability and recovery, para- and transcellular transport, as well as mucus production and analysis.
  • When it comes to disease modeling, we focus on biomarker profiling, inflammation, angiogenesis to capture tissue-level responses, extracellular vesicles, hypoxic conditions, and even microgravity, giving you access to advanced experimental settings beyond conventional models.

Our Service Includes Five Steps:

1. Choose Tissue Model Type

Established or custom model

2. Choose Test Compound

Drugs, biologics, immuno cells, microorganisms

3. Choose Application

Pharmacology, disease modeling, barrier function, host interaction

4. Choose methods of analysis

Assays and readouts tailored to your needs

5. Reporting

Comprehensive data package with figures, analysis, and interpretation

Key Advantages

We use primary cells, cancer cell lines, patient derived cancer cells, iPS-derived cells, and cell co-cultures. Our services cover multiple application areas, each supported by dedicated assays to generate the most relevant data.

Extended Model Longevity

Maintains functional tissue cultures longer than static systems ideal for long-term studies.

Anaerobic Microbiota Co-Culture

Maintains functional tissue cultures longer than static systems ideal for long-term studies.

Improved Barrier & Mucus Function

Shear stress affects epithelial integrity and enhanced mucus layer development.

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