Skip to main content

All in One System

Dynamic Organ Chip

A dynamic organ on chip platform with a vertically stacked channel design separating endothelial and epithelial channels with a permeable membrane. Micro engineered environment allows to recreate various organ on chip models such as kidney, gut, lung, blood-brain barrier, pancreas, and others.

Key Features

Cellbox Labs automated system allows for flexible experiment design and significantly reduces hands-on time. A modular manifold system gives the opportunity to expand the system's throughput from 8 to 24 chips.

High Dimensional Accuracy

Our mass manufacturing process guarantees exceptional reproducibility, achieving precision down to a few micrometers, ensuring consistency across every chip.

Low Chemical Adsorption

Made from COC (cyclic olefin copolymer), our chips offer significantly lower adsorption of small molecules compared to traditional PDMS, ensuring better retention and performance for your applications.

Controlled Gas Environment

Designed to maintain precise hypoxia and normoxia conditions, our chips enable accurate and reliable organ model development.

4. Software

Instrument is controlled via Software providing microscopy and controlled microenvironment.

Previous
Next
Download Specification ↓

Automated System

Cellbox Labs automated system allows for flexible experiment design and significantly reduces hands-on time. A modular manifold system gives the opportunity to expand the system's throughput from 8 to 24 chips.

Manifold

Using a pumping system and valves, provides flow to the organ chip and maintains a controlled environment for the experiment. The manifold functions as a compact incubator, providing the interface between the chip and the instrument. The integrated manifold delivers media through the organ chip while precisely regulating temperature, ensuring consistent conditions and enabling easy sample collection for downstream analysis.

Key Features

Automated system allows flexible experiment design and significantly reduces hands-on time.

Integrated Microscopy

Built-in bright-field microscopy enables real-time monitoring of cell cultures. The system automatically captures images of the entire channel in just 2 minutes, and microscopy can be conducted remotely from the comfort of your office or home.

User-Friendly Design

No prior experience with microfluidics is required. The system is intuitive and easy to operate, with straightforward software that allows you to design and execute experiments in just a few hours of training.

Unmatched Flexibility

The proprietary pumping system lets you set flow rates for each channel, enabling experiments with 1, 2, 3, or all channels simultaneously. You can also control media flow separately for the top and bottom channels, offering exceptional experimental customization.

4. Software

Instrument is controlled via Software providing microscopy and controlled microenvironment.

Previous
Next
Download Specification ↓

The Workflow

1. Chip Seeding

Chip is seeded with extracellular matrix (ECM) and cells.

2. Manifold

Then the chip is attached to the manifold with an easy-to-use locking system.

3. Reservoirs

Reservoirs are added to the manifold to store and collect media.

4. Culture Media

The culture media is perfused through the chip to maintain the microenvironment.

5. Software

The instrument is managed through software offering real-time microscopy, accessible both on-site and remotely.

Applications

Cancer Research 

Read More

Cancer Research 

Conventional cancer models often fail to capture the complexity of the tumor microenvironment, leading to poor translation from lab to clinic. Our organ-on-chip technology creates dynamic systems that more closely resemble human biology, enabling researchers to generate insights and results that conventional approaches miss.

What you can do:


→ Recreate disease- and tumor-specific microenvironments
→ Enable monitoring of pathophysiology in real time
→ Study metastasis and immune interactions
→ Test novel therapies and drug combinations
→ Study systemic cancer effects with multi-organ interactions

‍

For example:

We have developed and validated breast and lung cancer models on chip. MCF-7 cells and spheroid fragments were cultured under flow, revealing altered cancer stem cell marker expression and differential drug response to 4-hydroxytamoxifen compared to static cultures

Close

Precision Medicine

Read More

Precision Medicine

Every patient is unique, yet conventional models often overlook this individuality. By integrating patient-derived cells and organoids into our organ-on-chip systems, we enable personalized testing that predicts individual drug responses and supports tailored therapy selection.

What you can do:

→ Patient-derived cell cultures and organoids on chip
→ Patient – specific personalised testing iPCSs
→ Predict individual drug responses
→ Support personalized therapy selection

For example:

Patient-derived NSCLC organoids were cultured in chips and exposed to cisplatin, demonstrating patient-specific cytotoxicity and biomarker expression under dynamic conditions

Close

Hypoxia

Read More

Hypoxia

Ineffective preclinical models can slow drug development and increase costs. Our organ-on-chip solutions bring human relevance into the early stages of discovery, supporting more informed decisions and accelerating the path toward clinical validation.

What you can do:

→ Validate novel drug candidates using physiologically relevant human models
→ Predict human responses earlier
→ Reduce costly late-stage failures
→ Robust and reproducible high-throughput assays

Close

Toxicology & Safety Assessment

Read More

Toxicology & Safety Assessment

With our platform, you can assess compound safety in human-relevant models, detect organ-specific toxicity, and capture both acute and long-term exposure effects that conventional systems often miss.

What you can do:


→ Organ-specific toxicity detection
→ Chronic and acute exposure testing
→ Enable long-term exposure studies and low-dose effects analysis

Close
All Applications

Contract Research Services

We offer established models, including intestinal models, cancer models and vasculature models. In addition, we provide new model development with tailored designs based on your specific project needs.butt

Read More

Get in Touch

Send →

Thank you!

Thank you for getting in touch with us! We will contact you shortly!

Oops! Something went wrong while submitting the form.

Contract Research Services

We use primary cells, cancer cell lines, patient derived cancer cells, iPS-derived cells, and cell co-cultures.

Our services cover multiple application areas, each supported by dedicated assays to generate the most relevant data.

  • In in vitro pharmacology, we perform PK/PD studies, toxicity and efficacy testing, gene expression, imaging and cell functional assays.
  • For host–microbiota interaction, including strict anaerobes, we apply metagenomics, metabolomics, bacterial adhesion, and pre/probiotic validation.
  • In biological barrier transport and integrity, we measure induced permeability and recovery, para- and transcellular transport, as well as mucus production and analysis.
  • When it comes to disease modeling, we focus on biomarker profiling, inflammation, angiogenesis to capture tissue-level responses, extracellular vesicles, hypoxic conditions, and even microgravity, giving you access to advanced experimental settings beyond conventional models.

Our Service Includes Five Steps:

1. Choose Tissue Model Type

Established or custom model

2. Choose Test Compound

Drugs, biologics, immuno cells, microorganisms

3. Choose Application

Pharmacology, disease modeling, barrier function, host interaction

4. Choose methods of analysis

Assays and readouts tailored to your needs

5. Reporting

Comprehensive data package with figures, analysis, and interpretation

Key Advantages

We use primary cells, cancer cell lines, patient derived cancer cells, iPS-derived cells, and cell co-cultures. Our services cover multiple application areas, each supported by dedicated assays to generate the most relevant data.

Extended Model Longevity

Maintains functional tissue cultures longer than static systems ideal for long-term studies.

Anaerobic Microbiota Co-Culture

Maintains functional tissue cultures longer than static systems ideal for long-term studies.

Improved Barrier & Mucus Function

Shear stress affects epithelial integrity and enhanced mucus layer development.

Previous
Next
Close

Get Specifications

Download Specification ↓

Thank you!

The specification document will be opened in a new tab.

Oops! Something went wrong while submitting the form.
Close

Get Specifications

Download Specification ↓

Thank you!

The specification document will be opened in a new tab.

Oops! Something went wrong while submitting the form.
Close